The ealier the better to have cochlear implant

A new paper just has published on Science (2005 Dec 2;310(5753):1490-2. ) titled as Restoration of auditory nerve synapses in cats by cochlear implants. Dr. Ryugo's team at Johns Hopkins finished the work. The journal deemed the study as "valuable information to the field of not only cochlear implants, but the whole area of neuroscience research".

The works suggest that the ealier to have cochlear implant, the better the patient would benefit from the device.

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Don't hesitate to have a cochlear implant when you need it!

A new research has published in Journal of Neurophysiology (93:33339-3355), claiming that degradation of temporal resolution in the auditory midbrain after prolonged deafness is reversed by electrical stimulation of the cochlear.

 

Most clinician are conservertive to suggest to use CI for adult when he has been deaf for a long time. It is time now to try boldly for those patients.

Heeding the hormonal call

An enduring question in evolutionary biology is: How optimized are organisms for their environment? This question is perhaps best addressed in the field of sensory biology. It is straightforward to specify both sensory stimuli--such as species-specific communication signals, signals from predator or prey, or noise--and the transmission properties of the environment. Furthermore, it is easy to measure the ability of an animal's sensory system to pick up these signals. Some sensory receptors are sharply tuned to particularly potent signals, whereas others are broadly sensitive to the total array of signals encountered. Of particular interest are examples of apparent mismatches between communication signals and the sensitivity of the receptors receiving them. Could it be that an appropriate well-matched signal has not yet been found? Are the sensory receptors optimally tuned to a different signal that belongs to the evolutionary past? Is the mismatch exploited during, for example, the selection of a mate? Or, is the mismatch a reflection of the dynamic nature of matching between communication signals and sensory systems--that is, does the matching between sender and receiver change depending on the stage of the life cycle or environmental conditions? The answer is provided by Sisneros and colleagues on Science. 2004 Jul 16;305(5682):349-50., who chose as their subject the plainfin midshipman (Porichthys notatus), a nocturnal fish that inhabits Pacific coastal waters. These investigators resolve the apparent mismatch between a vocal mating signal emitted by the male fish and the sensitivity of the female's auditory system by demonstrating that steroid reproductive hormones increase the sensitivity of the female's auditory system to the male's courtship calls. (from Zakon H.)

Fw: Help Increase NIH Funding

ARO Members:

This year Congress is moving with uncharacteristic speed to write and pass its appropriations bills.  Consideration of the bill that contains funding for the National Institutes of Health (NIH) is expected to begin on June 8 in the U.S. House of Representatives. As you may know, the President has recommended just a 0.7% increase in NIH funding for this year, well below the 3.5% rate of biomedical research inflation.

Visit CapWiz, an on-line legislative action center, provided to you by SfN to send a letter to your Representative urging for increased funding: http://capwiz.com/sfn/home/

Thank you in advance for your participation.

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Sample Letter:

Dear Representative:

As consideration on the FY 2006 Labor, Health and Human Services, and Education (L-HHS) Appropriations bill moves forward, I urge you to include a 6 percent increase in funding for the National Institutes of Health (NIH).   As a constituent and member of the Association for Research in Otolaryngology, I am concerned with the state of biomedical research funding for this year.

As you may know, the President has recommended just a 0.7 percent increase in NIH funding for this year, well below the 3.5 percent rate of biomedical research inflation.  If enacted, the President's recommendation will actually move research backwards.  The recommendation would result in less funding and fewer grants awarded than in past years.

Reducing our investment in biomedical research has serious negative implications - not just for the health of the American people - but also for our economic strength as a nation, as Europe and Asia press forward with strong commitments to research.

The Association for Research in Otolaryngology represents more than 2,000 basic and clinical researchers from around the globe who are dedicated to improving the understanding of hearing and other communication disorders.  The U.S. commitment to advancing scientific progress and health benefits is dependent upon federal health dollars.

An increase of 6 percent is needed to meet inflation and restore funds that have been transferred for other purposes in the current year.  Please support at least a six percent increase in NIH funding in the FY06 L-HHS Appropriations bill.

Thank you for your consideration.

This letter was modified from a Society for Neuroscience request.

Animal's life saves human life! 

Fw: Auditory hair cell replacement by gene therapy in deaf mammals

This is a follow-up of similar gene therapy for hearing loss involved with hair cell, published in Nature medicine 13 February 2005.

 

An exciting discovery which will benefit certain senior people with hearing loss. However, we need to wait to see if it works for humans.

SRF mediates activity-induced gene expression and synaptic plasticity

Just published in Nature Neuroscience, 8 May 2005, the paper addressed the issue of synaptic activity-dependent gene expression, which is critical for certain forms of neuronal plasticity and survival in the mammalian nervous system.It is a very interesting advance in use-dependent modification of synaptic strength in the adult brain.

Noise can prevent progressive sensorineural hearing loss

Research paper has been published in J Comp Neurol. 2004 May 3;472(3):358-70. The research indicated that prolonged exposure to augmented acoustic environment on auditory system of middle-aged mice can prevent outer hair loss in the cochlear and save the neurons in the cochlear nucleus. It also implicates a sex difference.

 

According to the research, women should use hearing aid earlier to fight hearing loss after menopause or afflicted with hearing loss associated with menopause.

诺贝尔奖金得主的“尴尬” (A shameful story of a Nobel Prize Laureate)

       1975年，当年仅37岁的戴维 . 巴尔的摩登上诺贝尔领奖台时，他大概不会想到，拥有这样的殊荣，他的后半生的事业还会有波折。1986年他和他的一名助手Thereza Imanishi-Kari在Cell上发表了一篇免疫学方面的文章。Margot O'Toole当时是他们的一个博士后，受Thereza Imanishi-Kari的指导。Thereza Imanishi-Kari 把她的实验记录给Margot O'Toole，但是Margot O'Toole发现她并不能重复其中一些实验结果。她把这件事通了出来，这件事越闹越大，NIH和国会专门成立机构进行调查，巴尔的摩最后不得不撤回那篇论文。Margot O'Toole在事件发生后多年早不到工作，不得不到他弟弟的公司打工。Thereza Imanishi-Karibe被罚以不得从事联邦政府资助的研究多年，巴尔的摩的名誉在1992年后才开始挽回… …。